Volume 65, Issue 3

Semiparametric models: a generalized self‐consistency approach

A. Tsodikov

University of Utah, Salt Lake City, USA

Search for more papers by this author
First published: 08 July 2003
Citations: 31
A. Tsodikov, Division of Biostatistics, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112‐5550, USA.
E‐mail: atsodiko@hci.utah.edu

Abstract

Summary. In semiparametric models, the dimension d of the maximum likelihood problem is potentially unlimited. Conventional estimation methods generally behave like O(d3). A new O(d) estimation procedure is proposed for a large class of semiparametric models. Potentially unlimited dimension is handled in a numerically efficient way through a Nelson–Aalen‐like estimator. Discussion of the new method is put in the context of recently developed minorization–maximization algorithms based on surrogate objective functions. The procedure for semiparametric models is used to demonstrate three methods to construct a surrogate objective function: using the difference of two concave functions, the EM way and the new quasi‐EM (QEM) approach. The QEM approach is based on a generalization of the EM‐like construction of the surrogate objective function so it does not depend on the missing data representation of the model. Like the EM algorithm, the QEM method has a dual interpretation, a result of merging the idea of surrogate maximization with the idea of imputation and self‐consistency. The new approach is compared with other possible approaches by using simulations and analysis of real data. The proportional odds model is used as an example throughout the paper.

Number of times cited according to CrossRef: 31

  • Likelihood Transformations and Artificial Mixtures, Statistical Modeling for Biological Systems, 10.1007/978-3-030-34675-1, (191-209), (2020).
  • On a class of non‐linear transformation cure rate models, Biometrical Journal, 10.1002/bimj.201900005, 62, 5, (1208-1222), (2020).
  • On computation of semiparametric maximum likelihood estimators with shape constraints, Biometrics, 10.1111/biom.13266, 0, 0, (2020).
  • Confidence interval for the difference between two median survival times with semiparametric transformation models, Communications in Statistics - Simulation and Computation, 10.1080/03610918.2018.1563156, (1-17), (2019).
  • Fast Bayesian inference using Laplace approximations in a flexible promotion time cure model based on P-splines, Computational Statistics & Data Analysis, 10.1016/j.csda.2018.02.007, 124, (151-167), (2018).
  • Goodness-of-fit tests for the cure rate in a mixture cure model, Biometrika, 10.1093/biomet/asy058, (2018).
  • Estimation of delay time in survival data with delayed treatment effect, Journal of Biopharmaceutical Statistics, 10.1080/10543406.2018.1534857, (1-15), (2018).
  • A joint model of cancer incidence, metastasis, and mortality, Lifetime Data Analysis, 10.1007/s10985-017-9407-2, 24, 3, (385-406), (2017).
  • Joint modeling of time to recurrence and cancer stage at recurrence in oncology trials, Journal of Biopharmaceutical Statistics, 10.1080/10543406.2017.1289950, 27, 3, (507-521), (2017).
  • Nonparametric incidence estimation and bootstrap bandwidth selection in mixture cure models, Computational Statistics & Data Analysis, 10.1016/j.csda.2016.08.002, 105, (144-165), (2017).
  • Cure-Rate Survival Models and Their Application to Cancer Clinical Trials, Frontiers of Biostatistical Methods and Applications in Clinical Oncology, 10.1007/978-981-10-0126-0, (165-178), (2017).
  • undefined, 2015 IEEE International Conference on Data Mining, 10.1109/ICDM.2015.14, (1117-1122), (2015).
  • Joint modeling approach for semicompeting risks data with missing nonterminal event status, Lifetime Data Analysis, 10.1007/s10985-013-9288-y, 20, 4, (563-583), (2014).
  • Semiparametric regression analysis for time-to-event marked endpoints in cancer studies, Biostatistics, 10.1093/biostatistics/kxt056, 15, 3, (513-525), (2013).
  • Correcting the Results of the Wrong Model: Treatment Effects Under Early Detection of Cancer, Journal of Statistical Theory and Practice, 10.1080/15598608.2013.772033, 7, 2, (421-441), (2013).
  • Generating data from improper distributions: application to Cox proportional hazards models with cure, Journal of Statistical Computation and Simulation, 10.1080/00949655.2012.700714, 84, 1, (204-214), (2012).
  • A model-based statistic for detecting molecular markers associated with complex survival patterns in early-stage cancer, Journal of Clinical Bioinformatics, 10.1186/2043-9113-2-14, 2, 1, (14), (2012).
  • Temporal Trends in Long-Term Survival and Cure Rates in Esophageal Cancer: A SEER Database Analysis, Journal of Thoracic Oncology, 10.1097/JTO.0b013e3182397751, 7, 2, (443-447), (2012).
  • Checking semiparametric transformation models with censored data, Biostatistics, 10.1093/biostatistics/kxr017, 13, 1, (18-31), (2011).
  • Semiparametric Efficient Estimation for a Class of Generalized Proportional Odds Cure Models, Journal of the American Statistical Association, 10.1198/jasa.2009.tm08459, 105, 489, (302-311), (2010).
  • A self-consistency approach to multinomial logit model with random effects, Journal of Statistical Planning and Inference, 10.1016/j.jspi.2010.01.034, 140, 7, (1939-1947), (2010).
  • Maximum likelihood computation for fitting semiparametric mixture models, Statistics and Computing, 10.1007/s11222-009-9117-z, 20, 1, (75-86), (2009).
  • Weighted Breslow-type and maximum likelihood estimation in semiparametric transformation models, Biometrika, 10.1093/biomet/asp032, 96, 3, (591-600), (2009).
  • Case-cohort analysis with semiparametric transformation models, Journal of Statistical Planning and Inference, 10.1016/j.jspi.2009.04.023, 139, 10, (3706-3717), (2009).
  • Boosting method for nonlinear transformation models with censored survival data, Biostatistics, 10.1093/biostatistics/kxn005, 9, 4, (658-667), (2008).
  • Generalized self-consistency: Multinomial logit model and Poisson likelihood, Journal of Statistical Planning and Inference, 10.1016/j.jspi.2007.10.004, 138, 8, (2380-2397), (2008).
  • Maximum likelihood estimation in semiparametric regression models with censored data, Journal of the Royal Statistical Society: Series B (Statistical Methodology), 10.1111/j.1369-7412.2007.00606.x, 69, 4, (507-564), (2007).
  • Profile information matrix for nonlinear transformation models, Lifetime Data Analysis, 10.1007/s10985-006-9023-z, 13, 1, (139-159), (2006).
  • Chapter 10: The University of Rochester Model of Breast Cancer Detection and Survival, JNCI Monographs, 10.1093/jncimonographs/lgj010, 2006, 36, (66-78), (2006).
  • Functional inference in semiparametric models using the piggyback bootstrap, Annals of the Institute of Statistical Mathematics, 10.1007/BF02507025, 57, 2, (255-277), (2005).
  • Semiparametric Versus Parametric Regression Analysis Based on the Bounded Cumulative Hazard Model: An Application to Breast Cancer Recurrence, Parametric and Semiparametric Models with Applications to Reliability, Survival Analysis, and Quality of Life, 10.1007/978-0-8176-8206-4_25, (399-415), (2004).